Degradación del 4,5-diamino-2,6-dioxo-3-metil-1,2,3,6-tetrahidropirimidina en disolución acuosa

Se ha estudiado la cinética del proceso de degradación del 4,5-diamino-2,6-dioxo-3-metil-1,2,3,6-tetrahidropirimidina en disolución acuosa. El producto final del proceso de degradación se ha caracterizado mediante análisis químico, espectrofotometría de masas, IR y RMN, sugiriendo se para el, la fórmula correspondiente al 1 ,6-dimetil-2,4, 7 ,9-tetrahidroxipirimidina4,5, h-pteridina.The cinetic of the degradation process of the 4,5-diamine-2,6-dioxo-3-methyl1,2,3,6-tetrahidropyrimidine has been studied in aqueous solution. The fmal product of the degradation process has been characterized by means of chemical analysis, espectrofotometry of mass, IR, NMR, suggests that tite formula corresponds to 1 ,6-dimethyl-2,4, 7 ,9-tetrahidroxypyrimido4,5, h pteridine

Soundify: Matching Sound Effects to Video

In the art of video editing, sound helps add character to an object and immerse the viewer within a space. Through formative interviews with professional editors (N=10), we found that the task of adding sounds to video can be challenging. This paper presents Soundify, a system that assists editors in matching sounds to video. Given a video, Soundify identifies matching sounds, synchronizes the sounds to the video, and dynamically adjusts panning and volume to create spatial audio. In a human evaluation study (N=889), we show that Soundify is capable of matching sounds to video out-of-the-box for a diverse range of audio categories. In a within-subjects expert study (N=12), we demonstrate the usefulness of Soundify in helping video editors match sounds to video with lighter workload, reduced task completion time, and improved usability.Comment: Full paper in UIST 2023; Short paper in NeurIPS 2021 ML4CD Workshop; Online demo: http://soundify.c

Caracterización del 4,5-diamino-1,6-dihidro-1-metil-2-metiltio-6-oxo-pirimidina con vistas a su utilización como posible ligando

A partir de los espectros de absorción en la zona del ultravioleta e I. R., así como del espectro de R. M, N. se ha determinado la estructura más probable para la molécula de 4,5-diamino-1,6-dihidro-1-metil-2-metiltio-6-oxo-pirimidina. Asimismo, se ha estudiado la estabilidad térmica de esta sustancia a partir de los diagramas de A. T. D. Y T. G. Por último, se ha determinado el valor de su constante ácida, que es del orden de 10-12.From the absorption spectra in the ultraviolet and infrarred regions, and from the M NR spectrum, the most probable molecular structure of the 4,5-diamino-1,6-dihidro-1-methyl-2-methylthio-6-oxo-pyrimidine has been deter mined. The thermal stability of this substance has been studied from the D. T. A. and T. G. diagrams. The apparent acid constant of the mentioned substance has also been calculated

Complejos de cefalexina con cationes de elementos del cuarto periodo. I.-Estudio en disolución acuosa

Se ha investigado la formación de complejos, en disolución acuosa, de cefalexina [ácido 7-(D-2-amino-2-fenil-acetamido )-3-metil-8-oxo-S-tia-1-azabiciclo [4.2.O] oct-2-eno-2-carboxilico] con cationes de elementos del cuarto período, por métodos potenciométricos y espectrofotométricos. Se han determinado asímismo las constantes de formación de complejos.The formation of the complexes, in aqueous solution, between the cephaIexin and sorne ious of the fourth period elements has been investigated by potentiometric and spectrophotometric methods. The stability constants has been determinated

The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport

Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood. Here, we search for ubiquitin-related genes implicated in protein membrane trafficking performing a High-Content siRNA Screening including 1187 genes of the human “ubiquitinome” using amyloid precursor protein (APP) as a reporter. We identified the deubiquitinating enzyme PSMD14, a subunit of the 19S regulatory particle of the proteasome, specific for K63-Ub chains in cells, as a novel regulator of Golgi-to-endoplasmic reticulum (ER) retrograde transport. Silencing or pharmacological inhibition of PSMD14 with Capzimin (CZM) caused a robust increase in APP levels at the Golgi apparatus and the swelling of this organelle. We showed that this phenotype is the result of rapid inhibition of Golgi-to-ER retrograde transport, a pathway implicated in the early steps of the autophagosomal formation. Indeed, we observed that inhibition of PSMD14 with CZM acts as a potent blocker of macroautophagy by a mechanism related to the retention of Atg9A and Rab1A at the Golgi apparatus. As pharmacological inhibition of the proteolytic core of the 20S proteasome did not recapitulate these effects, we concluded that PSMD14, and the K63-Ub chains, act as a crucial regulatory factor for macroautophagy by controlling Golgi-to-ER retrograde transport

Acoustic radiation force impulse elastography and contrast-enhanced sonography of sinusoidal obstructive syndrome (veno-occlusive disease): Preliminary results

We report quantitative liver acoustic radiation force impulse (ARFI) elastographic findings in 2 cases of sinusoidal obstructive syndrome and liver contrast-enhanced sonographic features in one of these cases. To our knowledge, findings in this condition from these techniques have not been reported previously. Acoustic radiation force impulse elastography showed median high shear wave velocities (case 1, 2.75 m/s; case 2, 2.58 m/s) that normalized after specific treatment for sinusoidal obstructive syndrome; therefore, ARFI elastography provided quantitative information that helped diagnose this condition as well as monitor the response to treatment. Contrast-enhanced sonographic findings in one of the cases showed patchy liver enhancement that correlated with the high-velocity patchy distribution on ARFI elastography in that case and enhanced multidetector row computed tomographic findings in the other case. This contrast- enhanced sonographic pattern progressively normalized during follow-up after specific treatment. The elastographic features in both cases and contrast-enhanced sonographic features in one of them contributed to early diagnosis and follow-up of sinusoidal obstructive syndrome in both patients. Further prospective studies are necessary to define the role of ARFI elastography and contrast-enhanced sonography in the early diagnosis and clinical follow-up of this conditio

Copper tailing flocculation in seawater: relating the yield stress with fractal aggregates at varied mixing conditions

The implications of physical conditions of the feedwell on the rheological properties of synthetic copper tailings, flocculated in seawater, were analysed. The mixing intensity of flocculation was related to the structural characteristics of the aggregates, and the outcomes were linked to the yield stress of the pulp sediments. Tailings settling assays were conducted by using a 30 mm turbine type stirrer with an in-situ aggregate size characterisation. The structural characteristics of the aggregates were determined by using the focused beam reflectance measurement (FBRM). After a mixing time between the pulp and the flocculant, the sample was allowed to settle for 2.5 h, where the variation of the sediment height was minimal. The sediment was gently removed and subjected to rheological characterisation. The yield stress was measured on an Anton Paar MCR 102 rheometer (ANAMIN Group, Santiago, Chile), with a vane-in-cup configuration. The mixing intensity was related to the characteristics of the aggregates, and the outcomes were linked to the yield stress of the flocculated pulp sediments. More aggressive hydrodynamics deteriorated the structure of the aggregates, promoting the reduction of both its size and the fractal dimension. This brought direct consequences on the rheological properties of the sediments: at higher mixing level, the yield stress was lower. The explanation lies in the structural changes of the aggregates, where at a fixed mixing rate, the yield stress presented a seemingly exponential increase over the fractal dimension. Additionally, correlations were found between the rheological properties with settling rate and aggregate size.Ricardo I. Jeldres thanks Conicyt Fondecyt 11171036 and Centro CRHIAM Project Conicyt/Fondap/15130015. The authors are grateful for the contribution of the Scientific Equipment UnitMAINI of the Universidad Católica del Norte for supporting the experimental tests. Pedro Robles thanks the Pontificia Universidad Católica de Valparaíso for the support provided

Estudio de las interacciones sobre los iones Ca2+ con la imipramida y la maprotilina en medio acuoso. II. – Funciones termodinámicas de activación

A partir de los coeficientes de difusión, determinados a diferentes temperaturas, se han calculado las energías de activación de los procesos de difusión de los iones Ca2 + en las disoluciones acuosas, en ausencia y en presencia de imipramina y de maprotilina. Asimismo se han calculado las distancias cuadráticas medias netas por salto iónico, tiempo invertido en cada salto iónico, velocidades específicas netas de difusión, entalpías, entropías y energías libres de activacíón.The activation energies for the diffusion process of Ca2 + ions through aqueous solutions, with and without imipramine and maprotiline, have been caIculated from the diffusion coeflcients at different temperatures. The mean square distances for ionic jumps, mean times for ionic jumps, net specific velocities of diffusion, enthalpi-es, enthropies and free activation energies have be en also calculated

Transmission of optical communication signals through ring core fiber using perfect vortex beams

Orbital angular momentum can be used to implement high capacity data transmission systems that can be applied for classical and quantum communications. Here we experimentally study the generation and transmission properties of the so-called perfect vortex beams and the Laguerre-Gaussian beams in ring-core optical fibers. Our results show that when using a single preparation stage, the perfect vortex beams present less ring-radius variation that allows coupling of higher optical power into a ring core fiber. These results lead to lower power requirements to establish fiber-based communications links using orbital angular momentum and set the stage for future implementations of high-dimensional quantum communication over space division multiplexing fibers.Comment: 13 pages, 6 figure